dNTP Supply Gene Expression Patterns after P53 Loss

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dNTP Supply Gene Expression Patterns after P53 Loss

Loss of the transcription factor p53 implies mRNA losses of target genes such as the p53R2 subunit of human ribonucleotide reductase (RNR). We hypothesized that other genes in the dNTP supply system would compensate for such p53R2 losses and looked for this in our own data and in data of the Gene Expression Omnibus (GEO). We found that the de novo dNTP supply system compensates for p53R2 losses...

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ژورنال

عنوان ژورنال: Cancers

سال: 2012

ISSN: 2072-6694

DOI: 10.3390/cancers4041212